• br Cell origin The ontogeny of astrocytes

  2021-10-25

  

  Cell origin The ontogeny of astrocytes in vitro has been investigated in detail; Raff et al. (1983) characterised two types of astrocytes: type 1 being fibroblast-like in morphology and poorly labelled with a monoclonal antibody (AB25), whereas type 2 exhibited oligodendrocyte or neuron-like morp

• Peripheral injury or disease induced alterations in synaptic

  2021-10-25

  

  Peripheral injury- or disease-induced alterations in synaptic efficacy occur not only at the first synapse made by the primary nociceptive afferents in the spinal dorsal horn but are also operational in several regions processing the sensorimotor as well as emotional-affective components of pain, su

• It is important to underline that although ghrelin increases

  2021-10-25

  

  It is important to underline that 3,4-DAA although ghrelin increases the motivation to eat even in fed state, its effects on food intake and reward are blunted in obese animal models (Zigman et al., 2016). This emphasizes also the interconnection between homeostatic regulation of food intake and rew

• Galanin mediates its activity by

  2021-10-25

  

  Galanin mediates its activity by binding to three G-protein coupled receptor subtypes (designated GAL1-GAL3). Since GAL3 mRNA is found mainly in regions of the mesolimbic dopamine system, such as the ventral tegmental area, dorsal raphe nucleus, LC, amygdala, hippocampus, thalamus, hypothalamus, NAc

• Milnacipran HCl DAMPs are endogenous danger signals that can

  2021-10-23

  

  DAMPs are endogenous danger signals that can initiate and perpetuate a noninfectious Milnacipran HCl during cell death [23]. HMGB1 is a well-studied nuclear DAMP in various types of regulated necrosis and has been implicated in the pathogenesis of infection and sterile inflammation. Our current dat

• Biliary tract cancers BTC are

  2021-10-23

  

  Biliary tract cancers (BTC) are categorized into intrahepatic, perihilar, extrahepatic BTC (or cholangiocarcinoma) as well as gallbladder cancer (GBC). Although the incidence of BTC is low in developed countries (3% of gastrointestinal cancers), BTC is the second most common primary liver tumor afte

• SF1670 We found statistically significant association betwee

  2021-10-23

  

  We found statistically significant association between p95-HER2 levels and hormone receptor status, Ki-67 SF1670 and metastatic regions (p = 0.004,  0.05) and the median OS was 27.66 months versus 24.02 months for p95-HER2 positive and p95-HER2 negative BC patients respectively (p > 0.05). Finally,

• Introduction Hepatocellular carcinoma HCC is the fifth

  2021-10-23

  

  Introduction Hepatocellular carcinoma (HCC) is the fifth most lethal malignant tumor worldwide and is the second leading cause of cancer-related death [1]. For HCC patients, GPCR Compound Library virus (HBV) infection is the important causative risk factor in Asia-Pacific regions [[2], [3], [4]].

• br Acknowledgments This research was partially supported

  2021-10-23

  

  Acknowledgments This research was partially supported by the National Key Research and Development Program of China (2018YFD1000800); the National Natural Science Foundation of China (No. 31872943; No. 31501779 and No. 31372059>); 12th Five-Year State Science and Technology Support Program (2014B

• br Discussion The pattern of

  2021-10-23

  

  Discussion The pattern of activity exhibited by SSR 504734 and Lu AA21279 in the MEST test was very similar. Both compounds were inactive at the lowest dose (3.0mg/kg), but exhibited robust increases (∼150%) at 10mg/kg followed by a maximal detectable response at 30mg/kg. Based on the magnitude o

• The facts mentioned above indicate that glycine

  2021-10-23

  

  The facts mentioned above indicate that glycine function in brain is tightly regulated or pathologically altered mostly by glycine transporters. Modification of cytosolic regions of transporters, which interconnect them with intracellular regulatory pathways, could be one of the ways to provoke bra

• N Cadherin facilitated gap junction formation between embryo

  2021-10-23

  

  N-Cadherin facilitated gap junction formation between embryonic lens ODM-201 by stabilizing membrane appositions (Frenzel and Johnson, 1996). Cx43 has been found to be delivered to N-Cadherin-positive membrane HeLa cells (Shaw et al., 2007), and N-Cadherin determine the localization of Cx43 in card

• Here we investigated on epigenetic regulatory mechanisms of

  2021-10-23

  

  Here, we investigated on epigenetic regulatory mechanisms of ALX/FPR2 expression. Epigenetic changes, that include phosphorylation, acetylation, methylation and ubiquitination of DNA and histone proteins, occur in a variety of diseases [21] and are being recognized as key targets for personalized me

• We identified three genes KEAP NAA and

  2021-10-22

  

  We identified three genes—KEAP1, NAA38, and ABCC1/MRP1—as negative regulators of glutathione abundance in human cells. Like KEAP1, NAA38 appears to regulate NRF2 stability, as NAA38 deletion increased NRF2 protein levels and the expression of NRF2 target genes. NAA38 is a component of the NatC N-ter

• The deduced amino acid sequences of

  2021-10-22

  

  The deduced amino Cyclosporin A sequences of all scIPPSs display high similarity, and sequence alignments reveal seven conserved regions [2]. Regions II and VI contain the substrate-binding regions, with two characteristic aspartate-rich motifs (DDx(xx)xD; where x represents any amino acid residue)

16139 records 589/1076 page Previous Next First page 上5页 586587588589590 下5页 Last page